I used to have a S&W 22A with a 7" barrel. It was fine with the irons, but since it had an integral base I couldn't leave well enough alone. I mounted a 4x Leupold M8 in a set of Weaver rings. The results were phenominal. from a rest I could dump a ten round magazine of 36gr Fed HP cheapos into a buisiess card...at 100 yards! A lot of gophers and quite a few cotton-tail fell to this pairing. Bagged a 75 yard coyote, too. Also put down a standing-but-gutshot white-tail at about 50 yards with a behind the ear shot (I was guiding a friend: I had no rifle).
Alas, this story has a sad ending. Acurate though the gun was, it was a piece of crap in the durrability department. I had it repaired by S&W 3 times in the 3 years I had it. Most of the problems on this early 22a were corrected on later guns, but the charm was gone. I bought a 5" model years later, but it was not near as accurate.
Still got the Leopould though...