I have not dealt with .50 Beo, but I do have a .458 SOCOM and a .475 Tremor (.458 SOCOM necked for .475" bullets).
Whether or not anyone thinks that it will "do any good" to blend the receiver into the feed ramp, there is one simple point to make:
It won't hurt.
And... There really isn't any point in milling the barrel extension to aid feeding of these big, fat cartridges, unless you're going to blend the receiver into the barrel extension. It's a bit like putting french doors on your house and then bricking-over them.
Personally....
My .458 SOCOM was built on a cheap receiver with M4 cuts. The barrel extension was contoured by Tromix for the cartridge. I ignored their advice and didn't blend the receiver into the barrel extension, when I built the upper. It ran reliably - only giving me issues with some PMags (that didn't do well elsewhere, either) and low pressure handloads.
But, when it came time to put the .475 Tremor together, I blended that receiver and did the SOCOM while I had the tools out.
Feeding went from reliable, but hitchy and rough, to smooth and fast.
I was really surprised by what a huge difference was made by removing just a little bit of metal.
If I were building a .50 Beowulf, you can bet your backside that I'd blend the receiver into that barrel extension.
I'd think you would need to completely remove that center divider .
It doesn't need to be removed - just knocked down and blended a bit.
There's no point in removing the entire center from the M4 cuts, since doing so would require removing the locking lug directly in front of that area. And removing that locking lug usually doesn't work out well.
This is what Tromix recommends:
Feed ramp blending.