I would say yes you can. "IF" the bullet does not exceed the length of the chamber and cause the cylinder to bind, and if you follow accepted safe loading procedures. If you are going to do this in a revolver chambered for the 460, just use 460 brass; it would make things so much easier. Now if you want to use those bullets in a 454 casull chambered revolver, you'll have to take into consideration OAL, bullet weight,etc to make a safe load. That sounds like an interesting load to work up for the 454. I've found the my Ruger SRH dosen't like bullets under 230gr, even those are not what I would call accurate, but I have found that 250 gr XTP's are very deadly on deer at about 1250 fps.