I've been reloading the 454 Casull for years now using Winchester 296, Hornady 300gr XTP mag bullets and WSR primers. These loads shoot nicely and are very accurate.
If you like how they shoot -and- they are accurate...
Is there really, truly, any tangible way that you'd ever have any idea that a different primer might boost their speed by a little bit? If the net result is an increase in velocity -- would you notice, and/or, would you witness some manner of a gain?
Would I gain any advantage if I start using magnum primers?
It won't ever fit the guidelines of safe and proper handloading technique to merely switch primers and substitute a different (and hotter!) primer in to an already established load. That's a bad idea and most manuals have very specific warnings against it.
Thus, if you follow established safety related guidelines, you'd have to drop the load, and basically re-do your load development with a new primer. So... even -if- changing to a magnum primer might get you even better results than what you have now, there's no safe way for you to TRY that without re-developing the load.
And if you re-develop the load...
You'll have the answer of "will I gain?" far better by doing it than pretty much anyone could answer with either a guess or even their own hands-on experience. They don't have your revolver.
It sounds like you have a great "go-to" handload that gives you what you want right now. I don't see a lot of benefit in trying to improve upon it unless deep down... you aren't actually happy with the load.