In the revolver section of my safe, there are three 7.5" Redhawks 41,44, & 45 Colt, one Blackhawk in 30 Carbine, one Raging Bull 454, and one Colt Army 38 Spl.
I have loaded all of the RH's to the top end listed loads, that said, I usually do not make it a practice of shooting those loads o any sort of regular bsis. If there are any I DID it would have been the 180gr load listed in the Lyman #46 manual using 296. I have to add though, this isn't one for the faint of heart or recoil sensitive, and should be worked up to very carefully.
With the 45 Colt I have gone as high as 1250fps, and up to 310gr bullets. In all of my testing however, I have found no need to run the Colt loads any higher than 1150-1200fps with a 250gr bullet. In the artical by Brian Pearce on the three tiers of loads, I stick with the tier 1 & 2. No real need to go higher as these will both fully penetrate a 5 gallon bucket of sand lenghtwise with a RFN cast bullet. I figure that is more than good enough for anything I will be hunting in my woods. There is also something to say for the seemingly anemic 850 - 950fps loads as well. It might not be as flashy as the 44 magnum, but it is already starting out with almost 1/2" of frontal surface that DOES pack a whollop when it arrives.