I have a set of ballistics data from when our local sheriff and PD were selecting a .45 load. They tested Remington golden sabers, bonded sabers, Federal HS1, HST, and Speer Gold Dots, all in normal and +P loadings - 185gr and 230gr.
The test revealed the Federal HST 230gr load was almost always the best penetrating and expanding of the lot in bare gel, heavy clothing, wood, walls, car door, and glass tests.
Out of a 5" barrel the HST clocked 906 FPS avg with expansion to .97" and 13.47" of penetration in bare gelatin.
And don't use hardball for SD. It may work, but you severely increase your risk for over-penetration.