I'd prefer a sixgun that I can be sure of making fairly fast repeat shots without the need of removing the front sight from my forehead before making the second shot.
Any revolver stout enought to handle the .375 Winchester will be just about as light and easy to carry as a boat anchor. Not for me thank you. And I would not trust a semi-automatic as a woods bumming, bear defender, regardless of the chambering.
My choice would be one of three, a Ruger Super Blackhawk .44 RemMag, a Ruger Blackhawk .45 LC (with heavy loads), or a .454 Casull Freedom Arms if I could afford it Ruger Super Redhawk otherwise. The .44 Mag and the .45 LC would rank far ahead of the .454 because I am more accustomed to them and can control them better in rapid fire.
Larger might be better, but not if recoil prevents any necessary follow up shots.
Doc Hudson