There are a lot of pistol and rifle cartridges that will work as well or better for "home defense"
, and are less costly to practice with.
At best, the .300BLK is a niche cartridge designed to fill a niche role, which it does very nicely in
suppressed SBR (10") platforms. In that set up, it has potential military/SF uses, or in the hunting context, maybe as a very short-range, hearing-safe "hog blaster."
But that set up also makes it a two tax-stamp/NFA proposition, unless the weapon is a non-NFA "pistol"-type AR, but the can itself would still require a stamp.
Either way, once used in a real-world "home defense" shooting against an intruder, be assured the local Gendarmes will confiscate your weapon and suppressor, and then impound them into the police property lock-up. There they will remain until such time as someone in authority decides your use of deadly force was justified
... and even then you still may have to employ an attorney to get them returned. (A lot depends on the laws of your state regarding such matters).
Personally, if I'm forced to shoot an intruder, I'd rather have the coppers confiscate (even if only "temporarily") my 12ga Rem 870, or maybe my Glock 20 and 15-rd magazine, or maybe my Colt Series 70 1911 and 8-rd Wilson magazine, ... rather than my spendy, hyper-tacticool SBR and the can attached to it, no matter how fun it is to contemplate hosing-down a burglar or other home invader with it.