I have had a 280AI for about 20 years. I have shot some loads that would smoke any 7 Rem Mag factory ammo.
But, in the end I settled on 56 grains of REL 22 and 160 grain Nosler Partitions for everything. Regardless of what the manual says they actually chronograph in my rifle at 2770-2773 FPS. Very consistent velocity and they shoot fantastic. I've killed elk and deer with it, no problems. I'm sure I could stoke them up another 150-200 FPS, but don't really see the point.
Nosler makes the brass so you don't have to mess with fire forming, and in an emergency plain 280's will work fine.