The Ruger Single Six is a peach. Great fun to shoot and surprisingly accurate and powerful in .22 mag. My buddy has killed a couple of coyotes with his, one at almost 70 yards.
I've looked closely at the Heritage Rough Rider models which are basically a budget copy of the Single Six. They run about half the price but I haven't been impressed enough with the quality to spring for one. I shoot a lot and it just didn't seem like it would hold up in the long term.