The conventional wisdom is that 1 in 12 (or 1 in 13 or 14) is best with bullet weights of 35, 40, 45, 50, 52, and 55. So if it's a dedicated varminter gun, I'd run with remington. The 1 in 12 will shoot all of the above, plus 62/63, 68, and *possibly* 70, 75, and 77, but probably not the 75 & 77s. Likely though that it will not shoot the 35, 40, and 45s as well as the 1 in 12, though it may. So if it's more of an all-purpose gun, for larger critters like coyote or bigger, including defense vs. human predators, then go with the Savage.