I've got a Ruger MK III, 22/45, and a Ruger MK II. Good guns. 100% reliable? No, but I doubt any 22 is, especially if you're using standard run of the mill ammo. But they don't jam often.
Yes, they're a bit of a pain to strip down. Until you get the hang of it. Follow the directions to the letter, and it won't be a problem. Radical idea, huh?
The others mentioned are probably good, I just don't have any experience with them. I like the looks of the buckmark, and don't like the looks of the Walther.