Really light bullets 35-40gr in the .22-250?
Yes, they can travel at the speed of heat, and can group well at 100, but they are generally only a good short range setup. For ahooting at longer ranges, the 50, 52, 53, & 55 gr bullets of various makes and designs are the best. Heavier like 60 & 63gr often don't stabilize well in the "standard" .22-250 twist.
If you want ultra light bullets to do their best, you need a barrel with a slower twist than usual. If you want exra heavy bullets to do their best, you need a barrel with a faster than usual twist. Look what they are doing with the .223 and bullets of 70 to even 90 grains, using 1 in 9 or 1 in 7" twists! What do you think a .22-250 would do with a twist like that? But if it did, it likely would lose performance with lighter bullets.
Factory .22-250 barrels are generally optimised for the 55gr bullet. very light (40gr) and very heavy (60gr+) may work, but should not be expected to give as good a grouping as the 50-55gr stuff.