22-250
Sureshot, I take it that you know the reason for the arguments above against the nippy little .22?
It is just so that with even the best commercial bullets, when it impacts on anything this side of 200 yards it is going to break up, loose mass and momentum and may very well not reach the vitals.
At more than 300 yds it is not possible to exactly place that light (thus loosing energy very rapidly) projectile exactly, 90 degrees on, into that soft spot behind the shoulder.
After 300 it may not have enough momentum to go through the shoulder blade, or not deflect from a rib.